Cdh-2 and cortical f-actin dynamically cooperate to establish a stiffness gradient which contributes to forebrain roof plate invagination
Meenu Sachdeva, Prasenjit Sharma, Pankaj Gupta, Sweta Kushwaha, Mohd Ali Abbas Zaidi, Jonaki Sen
The paper investigates how mechanical forces and molecular interactions drive roof plate invagination in chick embryos, identifying Cdh2 and F-actin as key regulators of tissue stiffness gradients.
bioRxiv · Nov 3, 2025 · PreprintDevelopmental Biology