RAB5 NUCLEOTIDE BINDING PROMOTES β-OXIDATION TO FUEL HEPATOCELLULAR CARCINOMA CELL PROLIFERATION
Kelly Osayi Otakhor, Mohd Ali Abbas Zaidi, Rebecca E. Oberley‐Deegan, Moorthy Palanimuthu Ponnusamy, Kurt W. Fisher, Micah B. Schott
This study shows Rab5's GTPase cycle regulates lipid droplet dynamics in HCC cells, promoting β-oxidation and proliferation by sustaining mitochondrial energy production.
Journal of Biological Chemistry · Feb 25, 2026Peer-reviewedCancer Biology