Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysm
Khaled Abdelsattar Kassem Mohammed, Elisa Avolio, Valeria Vincenza Alvino, Eltayeb Mohamed Ahmed, Cha Rajakaruna, Ahmed Ghoneim, Ahmed Elminshawy, Gianni D. Angelini, Paolo Madeddu
This study shows that inhibiting MEK signaling with PD0325901 restores pericyte function and halts thoracic aortic aneurysm progression in mice.
bioRxiv · Feb 16, 2025 · PreprintCell Biology