Sequestration of the polyunsaturated fatty acids protects the cells with oxidative phosphorylation deficiency from ferroptosis
Guillermo Puertas-Frias, María José Saucedo-Rodríguez, Kristýna Čunátová, Lukáš Alán, Patrik Hrbac, Michal Knězů, Sona Konickova, Jakub Schimmer, Monika Krakovkova, Marek Vrbacký, Tomáš Čajka, Ondřej Kuda, Erika Fernández‐Vizarra, Massimo Zeviani, Hana Hansíková, , Alena Pecinová
The paper identifies that OXPHOS-deficient cells sequester polyunsaturated fatty acids into triacylglycerols to protect against ferroptosis, observed in patient fibroblasts and hypoxia conditions.
EMBO Reports · Aug 14, 2026Peer-reviewedCell Biology