Tissue Kallikrein 1 cleaves complement factor C3 and activates the alternative complement pathway
Sarah E. Sartain, Paula M. Jacobi, Virginie Qian, Briana Loredo, Mrinal Ranjan, Juan Leva Bueno, Saleh Bhar, Ang Li, Andrew Yee
This study shows that KLK1 cleaves complement factor C3 and activates the alternative complement pathway in HSCT-TMA, contributing to endothelial injury and renal dysfunction.
bioRxiv · Sep 8, 2025 · PreprintMolecular Biology