Author

Sarah E. Sartain

Michael E. DeBakey VA Medical CenterORCID 0000-0003-2204-4568Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

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Andrew YeeiD· 1 shared Ang LiiD· 1 shared Briana Loredo· 1 shared Juan Leva Bueno· 1 shared Mrinal RanjaniD· 1 shared Paula M. Jacobi· 1 shared Saleh BhariD· 1 shared Virginie Qian· 1 shared

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1 shared paperMolecular Biology

Andrew YeeORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintSep 8, 2025

Tissue Kallikrein 1 cleaves complement factor C3 and activates the alternative complement pathway

Sarah E. Sartain, Paula M. Jacobi, Virginie Qian…·Andrew Yee

This study shows that KLK1 cleaves complement factor C3 and activates the alternative complement pathway in HSCT-TMA, contributing to endothelial injury and renal dysfunction.

DOI 10.1101/2025.09.08.674260

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