SGLT2 inhibitors protect against diabetic cardiomyopathy and atrial fibrillation through a CaMKII independent mechanism
Alex Severino, Oscar E. Reyes Gaido, Pauline Nguyen, Ahmed M. A. Abd El-Karim, Elizabeth D. Luczak, Olurotimi O. Mesubi
This study shows SGLT2 inhibitors reduce diabetic cardiomyopathy and atrial fibrillation risk in T2D mice, but their effects are not dependent on CaMKII inhibition.
bioRxiv · Sep 23, 2024 · PreprintMolecular Biology