Author

Alex Severino

Johns Hopkins UniversityORCID 0000-0002-6567-8133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Elizabeth D. LuczakiD· 2 shared Oscar E. Reyes GaidoiD· 2 shared Ahmed M. A. Abd El-Karim· 1 shared An‐Chi WeiiD· 1 shared Bian LiuiD· 1 shared Erick O. Hernández‐OchoaiD· 1 shared Gabriel A. Lopez-CecetaiteiD· 1 shared Giovanni Rosales‐SotoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Elizabeth D. LuczakORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell type specific CaMKII activation patterns revealed by CaMKAR, a bioactivity reporter deployable in living cells

Alex Severino, Oscar E. Reyes Gaido, Bian Liu, Gabriel A. Lopez-Cecetaite, An‐Chi Wei, Giovanni Rosales‐Soto, Erick O. Hernández‐Ochoa, Elizabeth D. Luczak

The paper uses a CaMKII activity reporter to study activation patterns in cardiac, skeletal muscle, and neurons, revealing differences in activation rates and subcellular localization.

bioRxiv · Jun 11, 2025 · PreprintMolecular Biology

SGLT2 inhibitors protect against diabetic cardiomyopathy and atrial fibrillation through a CaMKII independent mechanism

Alex Severino, Oscar E. Reyes Gaido, Pauline Nguyen, Ahmed M. A. Abd El-Karim, Elizabeth D. Luczak, Olurotimi O. Mesubi

This study shows SGLT2 inhibitors reduce diabetic cardiomyopathy and atrial fibrillation risk in T2D mice, but their effects are not dependent on CaMKII inhibition.

bioRxiv · Sep 23, 2024 · PreprintMolecular Biology