Activation of STING due to COPI-deficiency
Annemarie Steiner [MSc], Katja Hrovat Schaale [PhD], Ignazia Prigione [PhD], Dominic De Nardo [PhD], Laura F. Dagley [PhD], Chien-Hsiung Yu [PhD], Pawat Laohamonthonkul, Cassandra R. Harapas [BSc], Michael P. Gantier [PhD], Marco Gattorno [MD], PhD] Stefano Volpi [MD, Sophia Davidson [PhD], Seth L. Masters [PhD]
This study identifies STING as a driver of inflammation in COPA syndrome and shows that STING inhibitors can reduce inflammation caused by COPI subunit deficiencies.
bioRxiv · Jul 9, 2020 · PreprintImmunology