Metabolomic Profiling Reveals Potential of Fatty Acids as Regulators of Stem-like Exhausted CD8 T Cells During Chronic Viral Infection
Katelynn R. Kazane, Lara Labarta-Bajo, Dina Zangwill, Kalle Liimatta, Fernando Vargas, Kelly C. Weldon, PC Dorrestein, Elina I. Zúñiga
This study identifies fatty acids as regulators of stem-like exhausted CD8 T cells during chronic viral infection, showing their impact on mitochondrial fitness and viral control.
Proceedings of the National Academy of Sciences · Jan 2, 2026Peer-reviewedImmunology