Action-outcome based flexible behavior requires medial prefrontal cortex lead and its enhanced functional connectivity with dorsomedial striatum
Áron Kőszeghy, Wei Xu, Mingshan Liu, Peiheng Lu, Long Wan, Peggy Seriès, Jian Gan
The paper investigates how the medial prefrontal cortex (mPFC) and dorsomedial striatum (DMS) interact during flexible decision-making in mice, finding that mPFC leads in tracking reward probability differences and enhances connectivity with DMS under low reward conditions.
bioRxiv · Dec 12, 2023 · PreprintNeuroscience