Self-supervised Internal Learning Enhances Isotropic Resolution for Three-dimensional Fluorescence Microscopy
Mingzhe Wei, Pengcheng Xu, Junyu Liu, Xuesong Li, Xuhui Feng, Jun Zhu, Renwei Dong, Hengjia Ran, Wentao Zhu, Yubing Han, Yue Li, Min Yi Guo, Huafeng Liu
This paper introduces DeepIso, a self-supervised framework that enhances isotropic resolution in 3D fluorescence microscopy by restoring axial frequency content without requiring explicit PSF models or system calibration.
Laser & Photonics Review · Sep 24, 2026Peer-reviewedBioengineering