Xuesong Li

Self-supervised Internal Learning Enhances Isotropic Resolution for Three-dimensional Fluorescence Microscopy

This paper introduces DeepIso, a self-supervised framework that enhances isotropic resolution in 3D fluorescence microscopy by restoring axial frequency content without requiring explicit PSF models or system calibration.

WHaloForce enables chemigenetic imaging of molecular tension in living cells and animals

WHaloForce is a chemigenetic tension sensor that enables quantitative imaging of molecular forces in living cells and animals, revealing distinct force patterns in different tissues.

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

This paper develops an optically cleared intervertebral window for long-term, high-resolution, inflammation-free in vivo imaging of mouse spinal cord dynamics.