TRPV1-Mediated Delivery of Chloroprocaine, a Local Anesthetic with High pKa, Produces Pain-Selective Anesthesia Without Neurotoxicity
Yishai Kushnir, Penker Sapir, Shaya Lev, Alexander M. Binshtok
This study shows that chloroprocaine, a high-pKa local anesthetic, when delivered via TRPV1 channels, provides prolonged pain-selective anesthesia without neurotoxicity.
bioRxiv · Feb 25, 2026 · PreprintNeuroscience