Alexander M. Binshtok

The paper uses voltage imaging to show ongoing action potential firing in nociceptor terminals in healthy mice, revealing electrical activity in peripheral axons.

This study shows that chloroprocaine, a high-pKa local anesthetic, when delivered via TRPV1 channels, provides prolonged pain-selective anesthesia without neurotoxicity.

This study shows that fatherhood in male mice enhances auditory cortex plasticity through prolactin signaling, improving pup vocalization discrimination.

The paper demonstrates that efferent signaling along nociceptive terminals increases during inflammation, leading to enhanced calcium signaling and mediator release in remote terminals.

The paper shows that spinal projection neurons reduce excitability during acute pain but not chronic pain, preventing pain chronification through increased potassium currents.

The paper shows that aging reduces inhibitory drive on excitatory spinal dorsal horn neurons, potentially contributing to increased pain sensitivity in older mice.

This study shows that silencing TRPV1-expressing fibers reduces colitis-induced visceral pain in rats by using QX-314 with TRPV1 activators or blockers.

The paper shows inflammation causes a distal shift of the axon initial segment in inhibitory spinal cord neurons, reducing their excitability and contributing to pain.

The paper investigates how spinal cord networks in mice encode inflammatory hyperalgesia through changes in neuronal activity and synaptic inhibition.

The paper shows that the input-output relation of primary nociceptive neurons depends on the morphology of their peripheral terminals and how multiple terminals integrate noxious stimuli.