Identification of novel bone-resorption markers by osteoclasts in vitro and in vivo
Brendan P. Norman, J. P. Dillon, S. M. Alkharabsheh, Francoise Congues, Peter J M Wilson, Andrew Davison, Elinor A. Chapman, J. Baker, Séamus Coyle, Christopher S. Probert, Paul E. Beaulé, Lakshminarayan R Ranganath, Jeremy Mark Wilkinson, James A. Gallagher
This study identifies 22 novel bone-resorption markers produced by osteoclasts in vitro and validates 14 in human biofluids, with two fragments elevated in bone metastasis urine.
JBMR Plus · Oct 11, 2025Peer-reviewedBiochemistry