Lakshminarayan R Ranganath

Liver-directed AAV gene therapy metabolically corrects AKU in Hgd deficient mice

This study demonstrates that liver-directed AAV gene therapy corrects metabolic defects in Hgd-deficient mice by restoring HGD expression and reducing HGA levels without hypertyrosinemia.

Identification of novel bone-resorption markers by osteoclasts in vitro and in vivo

This study identifies 22 novel bone-resorption markers produced by osteoclasts in vitro and validates 14 in human biofluids, with two fragments elevated in bone metastasis urine.

An anatomical investigation of alkaptonuria: Novel insights into ochronosis of cartilage and bone

This paper presents an anatomical study of alkaptonuria, revealing novel insights into ochronotic pigmentation in various tissues and highlighting differences in pigmentation patterns across different anatomical locations.