Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Steven W. Smeal, Chaitanya S. Mokashi, A Hyun Kim, Peter M. Chiknas, Robin Lee
The paper shows that prolonged IKK activation from time-varying cytokine stimuli leads to nuclear NF-κB retention via chromatin remodeling, with simulations accurately predicting single-cell responses.
Nature Communications · Aug 8, 2025Peer-reviewedSystems Biology