Structural mechanism for recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F
Peter Ngoi, Xianxi Wang, Sivasankar Putta, Ricardo Da Luz, Vitor Hugo Balasco Serrão, Michael J. Emanuele, Seth M. Rubin
The paper determines the structure of Cyclin F-Skp1 complex bound to E2F1 peptide, revealing differences in substrate-binding site and electrostatic interactions compared to Cyclin A.
Proceedings of the National Academy of Sciences · Jun 23, 2025Peer-reviewedBiochemistry