Leveraging distant relatedness to quantify human mutation and gene conversion rates
Pier Francesco Palamara, Laurent Francioli, Giulio Genovese, Peter Wilton, Alexander Gusev, Hilary Finucane, Sriram Sankararaman, Shamil Sunyaev
The paper quantifies human mutation and gene conversion rates using IBD segments and population history, finding higher mutation rates than pedigree-based estimates but lower than primate substitution rates.
bioRxiv · Jun 16, 2015Genetics