Author

Laurent Francioli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Shamil Sunyaev· 2 shared Alexander GuseviD· 1 shared Alexey S Kondrashov· 1 shared Alzheimers Disease Neuroimaging Initiative· 1 shared Georgii A Bazykin· 1 shared Giulio GenoveseiD· 1 shared GoNL Consortium· 1 shared Hilary Finucane· 1 shared

Activity by Year

2015-2017 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersEvolutionary Biology

Shamil Sunyaev

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2 papers

Recent·Most cited

Negative selection in humans and fruit flies involves synergistic epistasis

Mashaal Sohail, Olga A Vakhrusheva, Jae Hoon Sul, Sara Pulit, Laurent Francioli, GoNL Consortium, Alzheimers Disease Neuroimaging Initiative, Leonard H van den Berg, Jan H Veldink, Paul de Bakker, Georgii A Bazykin, Alexey S Kondrashov, Shamil Sunyaev

The paper detects underdispersion of rare loss-of-function alleles in humans and fruit flies, suggesting synergistic epistasis in negative selection.

Science · May 5, 2017Peer-reviewedEvolutionary Biology

Leveraging distant relatedness to quantify human mutation and gene conversion rates

Pier Francesco Palamara, Laurent Francioli, Giulio Genovese, Peter Wilton, Alexander Gusev, Hilary Finucane, Sriram Sankararaman, Shamil Sunyaev

The paper quantifies human mutation and gene conversion rates using IBD segments and population history, finding higher mutation rates than pedigree-based estimates but lower than primate substitution rates.

bioRxiv · Jun 16, 2015Genetics