Peter Wilton

This paper introduces a Bayesian framework for inferring population structure using IBD-based stochastic block models, showing improved accuracy over heuristic methods in both simulated and real data.

This study finds that higher polygenic risk scores for breast cancer are associated with longer survival in patients, suggesting a link between genetic predisposition and less aggressive tumors.

This study compares polygenic risk scores for Parkinson's disease across seven ancestries, finding varying predictive accuracy and highlighting the need for ancestry-specific models.

This study identifies genetic correlations between hyposmia and Parkinson's disease, finding a strong causal link from PD to hyposmia but weaker evidence for the reverse.

This study investigates the shared genetic architecture between rhythm and dyslexia using large-scale genome-wide association studies.

MUSSEL improves polygenic risk prediction across populations by integrating GWAS summary statistics and using Bayesian hierarchical modeling with ensemble learning.

This paper conducts a multi-ancestry genome-wide meta-analysis of Parkinson's disease, identifying 78 independent loci and 23 genes associated with PD risk.

The paper introduces CT-SLEB, a method for multi-ancestry polygenic prediction that improves performance in non-European populations using GWAS summary statistics and simulation studies.

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

This paper introduces Ancestry Composition, a pipeline for ancestry deconvolution that uses over 14,000 reference haplotypes to improve accuracy and scalability.

This paper introduces an approximate full-likelihood method to infer selection and allele frequency trajectories from DNA sequence data, showing improved power to detect selection compared to existing methods.

The paper develops a population-genetic framework to model mitochondrial heteroplasmy inheritance and applies it to infer genetic drift and mutation rates during human development.