Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis.
Jyothi Padiadpu, Manuel García‐Jaramillo, Nolan K. Newman, Jacob W. Pederson, Richard Rosario Rodrigues, Zhipeng Li, S. P. Singh, Philip M. Monnier, Giorgio Trinchieri, Kevin Brown, Amiran Dzutsev, Natalia Shulzhenko, Donald Β. Jump, Andrey Morgun
The paper identifies betacellulin as a target of omega-3 fatty acids in reducing NASH by suppressing inflammation and fibrosis through mechanisms involving hepatic stellate cells and macrophages.
EMBO Molecular Medicine · Oct 20, 2023Peer-reviewedSystems Biology