Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases
Siming Zhao, Jun Liu, Pranav Nanga, Yuwen Liu, A. Ercüment Çiçek, Nicholas Knoblauch, Chuan He, Matthew Stephens, Xin He
driverMAPS improves cancer driver gene detection by modeling positive selection and mutation patterns, identifying 159 new potential driver genes including RNA methyltransferases.
Nature Communications · Jul 30, 2019Peer-reviewedGenomics