Elastogenesis by adventitial progenitors acquiring a smooth muscle cell phenotype following aortic dissection
Sohei Ito, Preet Patel, Taishi Inoue, Ruizhi Wang, Yuriko Katsumata, Hong S. Lu, Kenji Okada, Alan Daugherty, Hisashi Sawada
This study identifies that adventitial progenitor cells differentiate into elastogenic SMC-like cells, contributing to false lumen remodeling through de novo elastic fiber formation following aortic dissection.
bioRxiv · Jun 16, 2026 · PreprintPathology