CBFA2T3-GLIS2 establishes transcriptionally permissive enhancer hypermethylation associated with venetoclax response in pediatric AML
Arundhati Chavan, Rhonda Ries, Pritam Biswas, Jason E. Farrar, Soheil Meshinchi, Samrat Roy Choudhury
The paper identifies enhancer hypermethylation as a feature of C/G AML linked to venetoclax response and shows DNMT3B inhibition enhances treatment efficacy.
bioRxiv · Oct 8, 2026 · PreprintCancer Biology