LFA-1 Interaction with GBP-130 on Plasmodium falciparum-infected Red Blood Cells mediates NK Cell Activation and Parasite Control
Osama Mukhtar, Ravi Dutt, Ashutosh Panda, Poonam Kumari, Suneet Shekhar Singh, Gourab Paul, Neha Prakash, Madiha Abbas, Md. Muzahidul Islam, Priya Arora, Alma Tammour, Asif Mohmmed, Dhiraj Kumar, Pawan Malhotra
This study identifies PfGBP-130 as the ligand for LFA-1 on Plasmodium falciparum-infected red blood cells, showing it mediates NK cell activation and parasite control.
bioRxiv · Aug 20, 2025Immunology