CircEPSTI1 regulates miR-942-5p-SERPINE1-AKT1 signaling axis to enhance dengue infection and is suppressed by Tiplaxtinin
Nilanjana Das, Pandikannan Krishnamoorthy, Kushal Ramrao Junghare, Athira S. Raj, Priyanka Saha, Kuhu Pal, Shouvanik Adhya, Atul Garg, Dheeraj Khetan, Ashok Kumar, Himanshu Kumar
This study identifies circEPSTI1 as a regulator of dengue infection through a miR-942-5p-SERPINE1-AKT1 signaling axis and shows that Tiplaxtinin suppresses this pathway to inhibit DENV replication.
Proceedings of the National Academy of Sciences · Oct 26, 2026Peer-reviewedImmunology