TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis
Q. Ju, W. Sheng, M. Zhang, J. Chen, L. Wu, X. Liu, W. Fang, H. Shi, C. Sun
This study shows that TAK1 phosphorylates PLCE1 at S1060, reducing PIP2 hydrolysis and inhibiting esophageal squamous cancer metastasis.
bioRxiv · Mar 22, 2024Cancer Biology