Detecting DNA methylation patterns suggestive of variable escape from X-chromosome inactivation
Qicheng Zhao, Ohanna Cavalcanti de Lima Bezerra, Kathleen Oros Klein, Mark Lamin, Marie-Claude Beaulieu, Marc Rodger, Michael Kovacs, Liam O'Neil, Carolyn J. Brown, Marie Hudson, Inés Colmegna, Sasha Bernatsky, France Gagnon, Anna K. Naumova, Qihuang Zhang, Celia M.T. Greenwood
The paper develops a statistical method to detect locus-specific escape from X-chromosome inactivation in DNA methylation data, applied to rheumatoid arthritis and venous thromboembolism datasets.
bioRxiv · Jun 19, 2026 · PreprintGenomics