Carolyn J. Brown

Detecting DNA methylation patterns suggestive of variable escape from X-chromosome inactivation

The paper develops a statistical method to detect locus-specific escape from X-chromosome inactivation in DNA methylation data, applied to rheumatoid arthritis and venous thromboembolism datasets.

Derivation of a minimal functional XIST by combining human and mouse interaction domains

The paper identifies a minimal functional XIST by combining human and mouse interaction domains to achieve targeted silencing and heterochromatic mark recruitment.

Contribution of epigenetic changes to escape from X-chromosome inactivation

The paper analyzes epigenetic marks to predict X-chromosome inactivation status and shows gene-level regulation of variably escaping genes.

A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta

The paper identifies sex-associated differentially methylated CpGs in term placenta DNA using two cohorts and links them to maternal age and birthweight.

Independent recruitment of PRC1 and PRC2 by human XIST

The paper identifies regions of human XIST essential for recruiting PRC1 and PRC2, showing independent pathways for chromatin modification and protein recruitment.

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing

The paper examines X-chromosome inactivation across 12 species, finding mouse as an outlier with fewer escape genes and highlighting domain-level control and gene-based influences on inactivation.

A role for YY1 in sex-biased transcription revealed through X-linked promoter activity and allelic binding analyses

The paper identifies YY1's role in X-linked gene escape from inactivation by analyzing promoter activity and allelic binding in human datasets.