Inés Colmegna

Detecting DNA methylation patterns suggestive of variable escape from X-chromosome inactivation

The paper develops a statistical method to detect locus-specific escape from X-chromosome inactivation in DNA methylation data, applied to rheumatoid arthritis and venous thromboembolism datasets.

Increased Expression and Altered Functional Activities of Immune Receptors TREM1, PD-L1, and Others on Hematopoietic Progenitor Cells in a Mouse Model of Rheumatoid Arthritis

This study shows that immune receptors on hematopoietic progenitor cells are upregulated in a mouse model of rheumatoid arthritis and that stimulating these receptors alters cell expansion and differentiation.

Low Dose Methotrexate has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells

This study shows low dose methotrexate (LD-MTX) differentially affects cycling and resting human hematopoietic stem and progenitor cells (HSPC), reducing proliferation while preserving clonogenicity in non-cycling cells.

Trained Immunity Affecting Dendritic Cell Differentiation and Function in Rheumatoid Arthritis

This study shows that trained immunity affects dendritic cell differentiation and function in rheumatoid arthritis, altering their gene expression and immune responses.