High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq
shen qingmei, Enze Deng, Ling Luo, Jing Zhang, Qifeng Yang, Dan Su, Xiaoying Fan
SpliCOOL-seq enables high-throughput co-profiling of DNA methylation and chromatin accessibility in single cells, revealing epigenetic heterogeneity in lung cancer subclones and drug response patterns.
Clinical and Translational Medicine · Jan 28, 2026Peer-reviewedGenetics