Dan Su

SpliCOOL-seq enables high-throughput co-profiling of DNA methylation and chromatin accessibility in single cells, revealing epigenetic heterogeneity in lung cancer subclones and drug response patterns.

The paper uses single-cell full-length transcriptome sequencing to study isoform regulation in developing mouse cortices, identifying dysregulated isoforms in Autism Spectrum Disorder.

This study investigates NEUROD1-induced astrocyte-to-neuron conversion using single-cell multiomics, revealing transcriptional and epigenetic changes and comparing it to ASCL1-induced conversion.