Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells
Aninda Mitra, Marie F.A. Cutiongco, Romina Burla, Yongpeng Zeng, Qin Na, Mengya Kong, Benjamin Vinod, Mui Hoon Nai, Barbara Hübner, Alexander Ludwig, Chwee Teck Lim, G. V. Shivashankar, Isabella Saggio, Wenting Zhao
The paper shows that acute chromatin decompaction increases nuclear stiffness in some cells but not others, depending on their ability to recompact chromatin.
Proceedings of the National Academy of Sciences · May 9, 2025Peer-reviewedBioengineering