Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinsons disease
Jakub Kopál, Andrew Vo, Qin Tao, Tanya Simuni, Lana M. Chahine, Danilo Bzdok, Alain Dagher
This study examines how LRRK2 pathogenic variants affect brain structure in Parkinson's disease patients and non-manifesting carriers, finding milder cortical atrophy in LRRK2 PD patients and no atrophy in carriers.
Communications Medicine · Jan 3, 2026Peer-reviewedGenetic & Genomic Medicine