Tanya Simuni

Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinsons disease

This study examines how LRRK2 pathogenic variants affect brain structure in Parkinson's disease patients and non-manifesting carriers, finding milder cortical atrophy in LRRK2 PD patients and no atrophy in carriers.

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

Machine Learning Prediction of Parkinson's Disease Onset and Subtype Using Germline Variants

This study uses machine learning to predict Parkinson's disease onset and subtype from germline variants, achieving ROC scores of 0.77 and 0.61.

Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression

This paper validates serum neurofilament light chain (NfL) as a biomarker for Parkinson's disease progression, showing increased levels in PD patients compared to healthy controls and a longitudinal increase correlating with clinical severity.