Putting a lid on it: The N-terminal helix of Arf1 inhibits switching via uniform stabilization of the native state
Edgar V Peters, Tejaswi Naidu Koduru, Noam Hantman, Scott A. McCallum, Qingqiu Huang, Jacqueline Cherfils, Catherine Ann Royer
This study shows that the N-terminal helix of Arf1 stabilizes the repressed state by globally stabilizing the native structure, rather than through specific interactions with the switch region.
bioRxiv · Apr 22, 2025 · PreprintBiophysics