Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and Htra1 Overproduction in Osteoarthritis
Garth Blackler, Joseph Daniel Klapak, Qinli Guo, Holly T. Philpott, HanYu Jiang, Dariana Ocica, Luigi Del Sordo, Benoit Fiset, Logan A. Walsh, C. Thomas Appleton
This study shows metabolic stress worsens osteoarthritis by altering synovial macrophage-fibroblast communication and increasing Htra1 expression.
bioRxiv · Sep 26, 2024 · PreprintPhysiology