Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization
X T Wang, Guanying Zhang, Mingda Hu, Jin Han, Chao Shang, Lejin Zhang, Zhengshan Chen, Ping Huang, Wentao Wang, Xinru Zhao, Yunzhu Dong, Yunxiang Zhao, Peng Lv, Xiaodong Zai, R H Jin, , Xiangyang Chi
This paper develops AENCS to engineer antibodies targeting glycosylated epitopes, demonstrating ACC01's 24-fold improved neutralization against SARS-CoV-2 variants.
bioRxiv · Jun 26, 2026 · PreprintBioengineering