Hongguang Ren

Base-mismatched crRNA in CRISPR Enabled Universal One-pot Rapid Nucleic Acid Detection

This paper introduces a one-pot CRISPR-Cas12a diagnostic strategy using base-mismatched crRNA, enabling rapid and specific detection of pathogens without PAM re-design or costly modifications.

SemVac: A Semantic Vaccinology Paradigm Powered by LLMs for Antigen Discovery

SemVac uses LLMs to predict vaccine antigens by analyzing literature-derived protein descriptions, outperforming existing methods and identifying new candidates with experimental validation.

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization

This paper develops AENCS to engineer antibodies targeting glycosylated epitopes, demonstrating ACC01's 24-fold improved neutralization against SARS-CoV-2 variants.

A Standardized Framework for Taxonomy Analysis in Bacterial Kingdom based on Protein Domain

The paper proposes a 3-step framework for bacterial taxonomy analysis based on protein domains and selects the best model candidates to improve classification accuracy and biological interpretation.

In vivo structure and dynamics of the RNA genome of SARS-Cov-2

This study maps the in vivo RNA-RNA interactome of SARS-CoV-2 during its life cycle, revealing structural features and dynamics that regulate replication, transcription, and frameshifting.

Taxonomy Analysis in Bacterial Kingdom based onProtein Domain: A Comparison Study

The paper proposes a 3-step framework for bacterial taxonomy analysis based on protein domains, selects the best model candidates, and provides taxonomy suggestions for NCBI.