Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes
M. Saeed, Z. Al-Karakooly, N. Ali, R. A. Ortmann
This study shows simvastatin induces apoptosis in rheumatoid arthritis synoviocytes by upregulating BNIP3 and inhibiting Akt, while increasing IL-6 and antioxidant gene expression.
bioRxiv · May 30, 2022 · PreprintImmunology