Enhanced immunogenicity of a synthetic DNA vaccine expressing consensus SARS-CoV-2 Spike protein using needle-free immunization
S. S. Alamri, K. A. Alluhaybi, R. Y. Alhabbab, A. Algaissi, S. Almahboub, M. A. Alfaleh, T. S. Abujamel, W. Abdulaal, M.-Z. ElAssouli, R. Alharbi, M. Hassanain, A. M. Hashem
This paper develops a synthetic DNA vaccine against SARS-CoV-2 and shows it induces strong Th1-biased immune responses in mice, with enhanced immunogenicity using a needle-free delivery system.
bioRxiv · Feb 1, 2021 · PreprintImmunology