Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids.
A. Chandrabalan, A. Firth, R. B. Litchfield, C. T. Appleton, A. Getgood, R. Ramachandran
This study identifies serine proteinases and matrix metalloproteinases as major PAR activating enzymes in OA synovial fluids, suggesting potential therapeutic targets for OA.
bioRxiv · Oct 21, 2020 · PreprintPharmacology & Toxicology