R. Ramachandran

Cochlear histopathology in macaques after noise-induced temporary threshold shifts

This study examines cochlear histopathology in macaques after noise-induced temporary threshold shifts, finding no significant loss of hair cells or synapses but chronic ribbon enlargement.

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

This paper presents a cryo-EM structure of Drp1 dimer revealing conformational rearrangements that regulate its self-assembly and mitochondrial fission.

Leveraging RAS-mSIN1 Interaction to Selectively Inhibit mTORC2 Employing Competitive RAS Binding Peptide: Implications in Breast Cancer Metastasis

The paper withdraws a manuscript due to incomplete experiments and requests that it not be cited as a reference.

dnaE2 expression promotes genetic diversity and bacterial persistence in mycobacterial biofilms

This study identifies dnaE2 expression as promoting genetic diversity and bacterial persistence in mycobacterial biofilms by reducing growth rate and mutation burden.

Autocrine Proteinase Activated Receptor (PAR) mediated signaling in prostate cancer cells.

This study identifies autocrine PAR signaling as a regulator of prostate cancer cell function through proteolytic enzyme-mediated cleavage and differential gene regulation.

Metformin Improves Ovarian Function and Increases Egg Production in Broiler Breeder Hens

This study shows metformin improves ovarian function and egg production in broiler breeder hens by reducing fat, normalizing follicular hierarchy, and altering hormone levels.

Conserved Pib2 regions have distinct roles in TORC1 regulation at the vacuole

This study identifies distinct functional regions in Pib2 that regulate TORC1 activity through differential localization and signaling mechanisms.

Temporal regulation of Pten is essential for retina regeneration in zebrafish

This study shows that Pten downregulation is essential for zebrafish retina regeneration by promoting Muller glia-derived progenitor cell proliferation through Akt and Mmp9/Notch pathways.

Chrysomycin A inhibits the topoisomerase I of Mycobacterium tuberculosis.

This study identifies chrysomycin A as an inhibitor of topoisomerase I in Mycobacterium tuberculosis, showing bactericidal activity and synergy with existing anti-TB drugs.

Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1

The paper shows that P-TEFb assembly and levels depend on reversible phosphorylation of cyclinT1 by PKC and dephosphorylation by PP1, leading to P-TEFb disassembly and CycT1 degradation in quiescent and terminally differentiated cells.

Kinetic pathway of ATP-induced DNA interactions of ParA2, a protein essential for segregation of Vibrio cholerae chromosome 2

This study investigates the kinetic pathway of ATP-induced DNA interactions of ParA2 in Vibrio cholerae, revealing its role in chromosome segregation through conformational changes and DNA binding dynamics.

Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids.

This study identifies serine proteinases and matrix metalloproteinases as major PAR activating enzymes in OA synovial fluids, suggesting potential therapeutic targets for OA.

Spatial separation of Streptomyces aerial mycelium during fermentation enhances secondary metabolite production

This paper introduces a method using glass marbles to spatially separate aerial and submerged mycelia in Streptomyces cultures, enhancing secondary metabolite production and reducing incubation time.

Role of the C-terminal tail in regulating Proteinase Activated Receptor 2 (PAR2) signalling

This study investigates how phosphorylation sites and palmitoylation in the C-terminal tail of PAR2 regulate signaling by affecting β-arrestin recruitment and MAPK activation.

Putative TetR family transcriptional regulator Rv1019 of Mycobacterium tuberculosis is an auto-repressor and a negative regulator of mfd-mazG operon

This paper identifies Rv1019 as an auto-repressor and negative regulator of the mfd-mazG operon in Mycobacterium tuberculosis, involved in DNA repair and persistence.

Proteinase-Activated Receptor 4 (PAR4) Activation Triggers Cell Membrane Blebbing through RhoA and β-arrestin

This study identifies that PAR4 activation triggers cell membrane blebbing through RhoA and β-arrestin, revealing biased signaling and transcriptional changes in PAR4-dependent pathways.

Molecular Basis for G-protein-Coupled Receptor (GPCR) Activation and Biased Signalling at the Platelet Thrombin Receptor Proteinase Activated Receptor-4 (PAR4)

This study identifies molecular determinants of PAR4 activation and biased signaling by analyzing peptide agonists and their interactions with the receptor.

Incursion of killer sponge Terpios hoshinota on the coral reefs of Lakshadweep archipelago

The paper documents the outbreak of killer sponge Terpios hoshinota on coral reefs in Lakshadweep and notes its expansion into isolated atolls of the Indian subcontinent.