Author

R. Barker-Clarke

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Biology Disciplines

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. E. Stacy· 1 shared D. T. Weaver· 1 shared E. Dolson· 1 shared E. S. King· 1 shared J. A. Maltas· 1 shared J. G. Scott· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperEvolutionary Biology

A. E. Stacy

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1 paper

Recent·Most cited

Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy

E. S. King, A. E. Stacy, D. T. Weaver, J. A. Maltas, R. Barker-Clarke, E. Dolson, J. G. Scott

The paper introduces a fitness seascape model to study drug resistance in E. coli by mapping genotypes to dose-response functions and shows that higher mutation supply and early drug adherence reduce resistance.

bioRxiv · Jun 10, 2022Evolutionary Biology