Author

J. A. Maltas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

J. G. Scott· 2 shared A. Durmaz· 1 shared A. E. Stacy· 1 shared A. Huynh· 1 shared A. Stocks· 1 shared D. Crozier· 1 shared D. T. Weaver· 1 shared E. Dolson· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersEvolutionary Biology

J. G. Scott

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3 papers

Recent·Most cited

Heterogeneous collateral effects in daptomycin-resistant E. faecalis

A. Huynh, J. A. Maltas, K. B. Wood

This study examines collateral effects of daptomycin resistance in E. faecalis, revealing diverse phenotypic outcomes and trade-offs in drug resistance and growth.

bioRxiv · Dec 7, 2023 · PreprintEvolutionary Biology

Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus

K. J. Card, D. Crozier, A. Durmaz, J. M. Gray, J. Creary, A. Stocks, J. A. Maltas, R. A. Bonomo, Z. D. C. Burke, J. G. Scott

This study evolves Staphylococcus aureus under vancomycin selection, revealing two distinct adaptive pathways that lead to divergent collateral sensitivity patterns to first-line antibiotics.

bioRxiv · Nov 30, 2023Evolutionary Biology

Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy

E. S. King, A. E. Stacy, D. T. Weaver, J. A. Maltas, R. Barker-Clarke, E. Dolson, J. G. Scott

The paper introduces a fitness seascape model to study drug resistance in E. coli by mapping genotypes to dose-response functions and shows that higher mutation supply and early drug adherence reduce resistance.

bioRxiv · Jun 10, 2022Evolutionary Biology