Author

R. C. Ford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Barbieri· 3 shared R. F. Collins· 2 shared T. Shafi· 2 shared A. Siebert· 1 shared E. R. Martin· 1 shared N. Thonghin· 1 shared N. Thongin· 1 shared R. C. Robinson· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

A. Barbieri

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3 papers

Recent·Most cited

Structure of ABCB1/P-glycoprotein bound to the CFTR potentiator ivacaftor.

A. Barbieri, N. Thonghin, T. Shafi, S. M. Prince, R. F. Collins, R. C. Ford

This study determines the structure of ABCB1/P-glycoprotein bound to ivacaftor and compares it to the drug-free state to understand binding mechanisms and conformational changes.

bioRxiv · Jun 11, 2021 · PreprintBiochemistry

In-vivo crystals reveal protein interactions

E. R. Martin, A. Barbieri, R. C. Ford, R. C. Robinson

The paper develops an in-vivo crystallization system to study protein interactions and applies it to analyze the NHERF1 PDZ2-CFTR complex, revealing new insights into residue-specific binding.

bioRxiv · Sep 26, 2019 · PreprintBiochemistry

Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9A resolution

N. Thongin, R. F. Collins, A. Barbieri, T. Shafi, A. Siebert, R. C. Ford

This study reports novel structural features of P-glycoprotein in the post-hydrolytic state using cryo-EM at 7.9Å resolution, revealing conformational changes and implications for drug transport and resistance.

bioRxiv · Apr 25, 2018Biochemistry