Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction
R. A. Kumar, D. Hahn, R. C. Kelley, D. R. Muscato, A. Shamoun, N. Curbelo-Bermudez, W. G. Butler, S. Yegorova, T. E. Ryan, L. Ferreira
This study shows that Nox4 knockout prevents diaphragm force loss in HFrEF mice, while Nox2 knockout provides partial protection and improves survival after myocardial infarction.
bioRxiv · May 27, 2022Physiology