L. Ferreira

Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism

This study shows physical activity reduces breast cancer risk by improving HSC function and enhancing cancer immunosurveillance through reduced oxidative stress and altered T cell differentiation.

Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction

This study shows that Nox4 knockout prevents diaphragm force loss in HFrEF mice, while Nox2 knockout provides partial protection and improves survival after myocardial infarction.

Cardiac and respiratory muscle responses to dietary N-acetylcysteine in rats consuming a high-saturated fat, high-sucrose diet

This study examines the effects of a high-saturated fat, high-sucrose diet and N-acetylcysteine supplementation on cardiac and respiratory muscle function in rats, finding diet-induced cardiac hypertrophy and dysfunction that were partially mitigated by NAC.

Mitotic exit is controlled during anaphase by an Aurora B-Cyclin B1/Cdk1 crosstalk

The paper shows that Cyclin B1 degradation during anaphase, regulated by Aurora B and kinesin-6, is essential for mitotic exit, reconciling the 'clock' and 'ruler' models.

Immunization with recombinant enolase of Sporothrix spp (rSsEno) confers effective protection against sporotrichosis in mice

This study shows that immunization with recombinant enolase (rSsEno) of Sporothrix spp, combined with Montanide Pet-GelA, increases antibody titers and survival in mice against sporotrichosis.

Single-cell RNA-Sequencing uncovers transcriptional states and fate decisions in haematopoiesis

This study uses single-cell RNA sequencing to reconstruct the blood lineage tree in zebrafish and identify transcriptional states and fate decisions during haematopoiesis.